Oleksandyr Usyk vs Prime Mike Tyson

The problem with Tyson is he never fought all time greats during his peak.

We all know straight athleticism, technique and power could overwhelm anyone. Tyson had that.
We also know people could crumble when tested in real battle against real hardships. Prime Tyson has never been tested this way.

Tyson also had weaknesses, but none of his opponents were good enough to really capitalize on it. Well, Tony Tucker did, but he seriously injured his hand in the first. They still went 12 rounds despite that. Go figure.

So in theory Tyson could beat anyone, but anyone good enough could also beat him. I'd give the edge to Usyk.