Re: Prime MJ & Pippen vs Prime LeBron & Wade
MJ and Pip easily. Not only MJ/Pip fits better with no redundancy, but also defense matter more than most fans gives it credit, and they are defensively leaps and bounds better than LeBron/Wade.
Offensively there is only one ball, and MJ is the best of them all. MJ/Pip are better passing duo too. Lets not forget mental aspect and clutchness - LeBron/Wade may or may not show up, but at least with MJ I know he will show up 110% every time it matters, and in the clutch he is again much better than LeBron/Wade.
Health - Wade is injury prone, the rest were more or less iron man.
As I said - easy choice.