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Old 01-17-2007, 06:50 PM   #1
Heilige
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Default OT: Small molecule offers big hope against cancer

DCA is an odourless, colourless, inexpensive, relatively non-toxic, small molecule. And researchers at the University of Alberta believe it may soon be used as an effective treatment for many forms of cancer.

Dr. Evangelos Michelakis, a professor at the U of A Department of Medicine, has shown that dichloroacetate (DCA) causes regression in several cancers, including lung, breast, and brain tumors.

Michelakis and his colleagues, including post-doctoral fellow Dr. Sebastian Bonnet, have published the results of their research in the journal Cancer Cell.

Scientists and doctors have used DCA for decades to treat children with inborn errors of metabolism due to mitochondrial diseases. Mitochondria, the energy producing units in cells, have been connected with cancer since the 1930s, when researchers first noticed that these organelles dysfunction when cancer is present.

Until recently, researchers believed that cancer-affected mitochondria are permanently damaged and that this damage is the result, not the cause, of the cancer. But Michelakis questioned this belief and began testing DCA, which activates a critical mitochondrial enzyme, as a way to "revive" cancer-affected mitochondria.

The results astounded him.

Michelakis and his colleagues found that DCA normalized the mitochondrial function in many cancers, showing that their function was actively suppressed by the cancer but was not permanently damaged by it.

More importantly, they found that the normalization of mitochondrial function resulted in a significant decrease in tumor growth both in test tubes and in animal models. Also, they noted that DCA, unlike most currently used chemotherapies, did not have any effects on normal, non-cancerous tissues.

"I think DCA can be selective for cancer because it attacks a fundamental process in cancer development that is unique to cancer cells," Michelakis said. "Cancer cells actively suppress their mitochondria, which alters their metabolism, and this appears to offer cancer cells a significant advantage in growth compared to normal cells, as well as protection from many standard chemotherapies. Because mitochondria regulate cell death--or apoptosis--cancer cells can thus achieve resistance to apoptosis, and this appears to be reversed by DCA."

"One of the really exciting things about this compound is that it might be able to treat many different forms of cancer, because all forms of cancer suppress mitochondrial function; in fact, this is why most cancers can be detected by tests like PET (positron emission tomography), which detects the unique metabolic profile of cancer compared to normal cells," added Michelakis, the Canada Research Chair in Pulmonary Hypertension.

Another encouraging thing about DCA is that, being so small, it is easily absorbed in the body, and, after oral intake, it can reach areas in the body that other drugs cannot, making it possible to treat brain cancers, for example.

Also, because DCA has been used in both healthy people and sick patients with mitochondrial diseases, researchers already know that it is a relatively non-toxic molecule that can be immediately tested in patients with cancer.

Furthermore, the DCA compound is not patented and not owned by any pharmaceutical company, and, therefore, would likely be an inexpensive drug to administer, Michelakis added.

However, as DCA is not patented, Michelakis is concerned that it may be difficult to find funding from private investors to test DCA in clinical trials. He is grateful for the support he has already received from publicly funded agencies, such as the Canadian Institutes for Health Research (CIHR), and he is hopeful such support will continue and allow him to conduct clinical trials of DCA on cancer patients.

"This preliminary research is encouraging and offers hope to thousands of Canadians and all those around the world who are afflicted by cancer, as it accelerates our understanding of and action around targeted cancer treatments," said Dr. Philip Branton, Scientic Director of the CIHR Institute of Cancer.

Source: University of Alberta


This news is brought to you by PhysOrg.com

http://www.physorg.com/printnews.php?newsid=88194392


This is great news for those of us who have cancer in our families.
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Old 01-17-2007, 06:53 PM   #2
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OT: Heilige, any reason why you chose that user name?
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Old 01-17-2007, 06:54 PM   #3
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This is great news for those of us who have cancer in our families.


which is pretty much everybody today.
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Old 01-17-2007, 06:54 PM   #4
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yes. i can smoke again.
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Old 01-17-2007, 06:57 PM   #5
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Default It is...

It is, but don't get too excited early.

Im doing my phd in chemistry, and used to do anti-cancer research. Theres a massive difference in compounds killing cancer cells in a petri dish and killing cancer in humans without any side effects.

I successfully made a couple compounds that have promise, but anything still in the phase theyre talking about is still incredibly far off, and an incredible longshot to actually make it to market.

That's not to say this isn't good news or promising by any means, but stories like this tend to make it seem as though anti cancer pills are a year away.

However, all of this stuff adds up. Researchers use previous work to move forward, and it's really important that schools get funding to do work like this that everyone can use and build on.
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Old 01-17-2007, 08:58 PM   #6
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I tend to ignore these findings. what people don't realize is that cancer is about 100 things going on at once and once you deactivate something, something else gets triggered. It will never completely solve cancer but will probably just be used as another alternative
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Old 01-17-2007, 09:02 PM   #7
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Quote:
Originally Posted by bjtrdff
It is, but don't get too excited early.

Im doing my phd in chemistry, and used to do anti-cancer research. Theres a massive difference in compounds killing cancer cells in a petri dish and killing cancer in humans without any side effects.

I successfully made a couple compounds that have promise, but anything still in the phase theyre talking about is still incredibly far off, and an incredible longshot to actually make it to market.

That's not to say this isn't good news or promising by any means, but stories like this tend to make it seem as though anti cancer pills are a year away.

However, all of this stuff adds up. Researchers use previous work to move forward, and it's really important that schools get funding to do work like this that everyone can use and build on.

Exactly. Cancer has been 'cured' like 20 times in the last 50 years... It is harder than it seems at first. While I was at the University of Medicine I studied cancer from the DNA and molecular biology aspect. It looked to be to huge a problem for me to even get really involved in.
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Old 01-17-2007, 09:04 PM   #8
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Good news to here hopefully we can keep making breakthroughs to further increase the chance of cancer survival.
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Old 01-17-2007, 09:07 PM   #9
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Default Cancer

The problem isnt necessarily curing cancer, it's curing cancer without destroying the body with horrible side effects.
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Old 01-17-2007, 09:08 PM   #10
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also, this finding is worthless compared to current methods in oncology. it will never replace radiation therapy. just to clarify
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Old 01-17-2007, 09:21 PM   #11
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Suddenly everyones a doctor
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Old 01-17-2007, 09:30 PM   #12
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what did you expect. this is a basketball forum. everyone is a doctor here.
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Old 01-18-2007, 11:56 AM   #13
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Quote:
Originally Posted by Run&Gun=Fun
Suddenly everyones a doctor
I'm a 1st year med student
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