This is the most highly anticipated movie of the year for me because it is by acclaimed director Darren Aronofsky, who also happens to be my favorite director. It's a hard film to explain, but here's a short summary from another site.
"Three parallel stories -- involving spirituality, love, and the fragility of existence -- as told through the life of Thomas, a man on a thousand-year journey to save the woman he loves. His epic journey begins as a conquistador in sixteenth-century Spain, where he commences his search for the Tree of Life, the legendary entity believed to grant eternal life to those who consume its sap. As a modern-day scientist, he desperately fights to find a cure for the cancer ravaging his beloved wife. Traveling through deep space as a twenty-sixth-century astronaut, he finally begins to grasp the mysteries of life which have fascinated him for more than a century."
Know that you will only enjoy this film, if you actually take the time to pay attention during it, it's a film that you may find pretentious, but my also find life changing, I think it's worth a shot. Here's the trailer: