Yep. Someone mentioned the best already. I was completely in love with B&B. I still watch it, frequently but its still the best show. Aside from that there's not really a debate. Maybe Cailou but that turned out pretty lame.
My favourite was always Transformers. Is it just me but does anyone else hate the remakes they make of cartoons now-a-days. I don't like any of this Transformers Cybertron rubbish, or the new He-Man, the only one I do watch is the new TNMT which I like more then the original cartoon.
They are supposed to be making a Smurfs movie, which is just a horrible idea. But it's to be expected.