I don't consider it 'OWNED" by a came, but in Guitar Hero 2, I've been stuck on Jordan on expert for the longest time.It's sohard. I've 4 starred TTFAF in GH3 on expert, but came no where near beating Jordan.
I can't think of any great examples, but I'm sure I'll think of some soon. However, I remember when I first played Fight Night Round 3, I tried to throw the Special Punch every time, because it worked for me at my friend's house, and for the first few fights I was frustrated and wanted to quit. However, I stopped doing that, and now the game seems awesome.
The first game that I could not beat was friggin Donkey Kong 64 for the N64. I got all the way to the final boss (where you box King K Rule.. or whatever his name is) and I could only get to the part where tiny goes in his shoe and shoots his toes. I finally quit playing it because I could NOT beat it... this was about 6 or 7 years ago. This past summer I found my good ol N64 and started where I left off and beat it on my second try.. I guess I just sucked back then. It's also the funnest game I have ever played.