Yes it's easy. Today's graphics cards go in the PCIe x16 slots on your motherboard. (The long white/red slots in this picture
are PCIe x16 slots.) There are three PCIe x16 slots on this motherboard
. One is white and the other two are dark blue.
Have a look at this video card
. There are gold colored teeth at the bottom of it. That's what plugs into the PCIe x16 slot.
Motherboards come in different size classes (not just sizes). All motherboards within a size class will have the screw holes in the same place, so you don't have to worry. As long as the motherboard has a PCIe x!6 slot and there is enough room in your computer case, you can put any PCIe x16 graphics card in it.