Michael Wallace of ESPN reports:

Miami Heat guard Dwyane Wade injured his right ankle in the third quarter of Sunday’s All-Star Game and did not return.

Wade sustained the injury midway through the quarter when he landed awkwardly on guard Deron Williams’ foot. Wade, a starting guard for the Eastern Conference team, had scored 14 points in the game before he limped off the court after East coach Doc Rivers called a timeout with 5:04 left in the quarter. He also had four rebounds and two assists in 21 minutes of the East’s 148-143 loss to the West.